Discovery of biomarkers in breath: Efficient screening with TD–GC–TOF MS

This study describes an analytical system for the rapid identification of potential disease biomarkers in breath, through the use of sampling onto TD tubes, followed by automated preconcentration and GC–TOF MS. Key advantages of the system described are easy‑to-use non-invasive sampling, high sensitivity through the use of trap-based focusing and an inherently sensitive detector, and software tools for improving workflow and automating the comparison of samples.

The approach uses TOF-DS™ software to baseline-compensate, integrate, deconvolve and library-search the data while the sample is being acquired. The value this brings is illustrated by the confident identification of four co-eluting analytes, which would have been very challenging to achieve using conventional sampling and analysis methods.

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