Tackling the extended list of fragrance allergens by flow-modulated GCxGC–TOF MS

This preliminary study investigates the use of flow-modulated GCxGC to analyse an 84-component allergen calibration standard, with simultaneous detection by TOF MS for confident identification and FID for robust quantitation.

A high degree of linearity and repeatability is demonstrated, showing that flow-modulated GCxGC is a promising approach for high-throughput quality control of fragranced products. The validity of the GCxGC–TOF MS/FID method is then demonstrated with the examples of essential oils and a fragrance mix.

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