Biological Monitoring

The growing use of small-molecule biomarkers for health-related research demands the separation and identification of structurally similar compounds in highly complex matrices – a challenge for which TD preconcentration, GC×GC separation and TOF MS detection technologies are very well-suited.

Uncovering hidden compositional changes in breath profiles using untargeted chemometric workflows

This study describes the use of thermal desorption (TD) and GC×GC–TOF MS for exploratory profiling of biomarkers in breath, coupled with innovative data mining tools to uncover hidden compositional changes using automated untargeted workflows.

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Discovery of biomarkers in breath: Development and optimisation of a TD–GCxGC–TOF MS analytical platform

This study describes the development of an analytical platform based upon TD–GCxGC–TOF MS and shows its application to the collection and analysis of breath samples. The enhanced separation achieved ensures confident identification of biomarkers.

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Discovery of biomarkers in breath: Efficient screening with TD–GC–TOF MS

This study describes an analytical system for the rapid identification of potential disease biomarkers in breath, through the use of sampling onto TD tubes, followed by automated preconcentration and GC–TOF MS.

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Discovery of biomarkers in breath: Enhancing separation and identification using GCxGC–TOF MS

This study describes the comprehensive, high-sensitivity screening of disease biomarkers, through use of sampling onto TD tubes, automated preconcentration, and GCxGC–TOF MS, with confident identification aided by Tandem Ionisation.

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